Proteolytic enzymes in the zymogen form to treat sarcoma cells

PAT 00-00-85 04514388 NDN- 167-0112-8342-1

INVENTOR(S)- Psaledakis, Nicholas G.

PATENT NUMBER- 04514388
PATENT APPLICATION NUMBER- 517801
DATE FILED- 1983-07-27
PATENT DATE- 1985-04-30
NUMBER OF CLAIMS- 3
EXEMPLARY CLAIMS- 1
ART/GROUP UNIT- 128
PRIMARY INDUSTRY- 93-01-BK; 93-01-BK
PATENT CLASS- Invention (utility) patent
INVENTOR COUNTRY/ZIPCODE- 01852
ATTORNEY, AGENT, OR FIRM- Gordon, Edward A.
U.S. PATENT CLASS- 424094100O
INTERNATIONAL PATENT CLASS- A61K03754; A61K037547
PATENT REFERENCED BY- 04695458; 04844897
PATENT STATUS INFO- 08/29/89, Expiration Due to Failure to Pay Maintenance
Fees, (EXP); 08/29/89, Expiration Due to Failure to Pay Maintenance Fees,
(EXP)

A method and composition is disclosed for the prophylactic treatment of
cancer tumor cells contained in a host body having a natural immunological
system and wherein the tumor cells have a protective surface resistant to
the immunological system, to prevent or at least reduce further development
of the tumor cells comprising; introducing a solution of a proenzyme and a
pharmaceutically acceptable carrier into the host body adjacent the tumor
cells, the solution having a concentration of the proenzyme at least in
excess of the proenzymes produced by the host body in the area of the tumor
cells, and contacting the tumor cells with the proenzyme whereby the
proenzyme is converted to its active form which reacts with the tumor cell
surface to sufficiently decompose the surface to permit the natural
immunological system to prevent or reduce development of tumor cells.
EXEMPLARY CLAIMS- Claim- 1. A method for the prophylatic treatment of
sarcoma cancer tumor cells in a host body to prevent or at least reduce
further development of said tumor cells comprising contacting said tumor
cells with a proenzyme selected from the group consisting of trypsinogen,
chymotrypsinogen and mixtures thereof in a concentration at least in excess
of said proenzymes produced by the host body in the area of said tumor
cells.